Scans could predict onset of schizophrenia

A positron emission tomography brain scan of a schizophrenic patient

An Edinburgh University study has shown people who later develop schizophrenia suffer from an accelerated brain shrinking before they become unwell.

Schizophrenia is a condition involving delusions and hallucinations.

It is associated with a reduction in brain tissue but the timing of these changes has, until now, been unclear.

Schizophrenia affects one in every 100 people.

The study examined people at high risk of schizophrenia who had two close relatives with the disorder and were between 16 and 25 at the beginning of the research.

This is the first time such changes in the brain size have been found in people at high risk of schizophrenia before they develop any symptoms.

Unlike previous studies, the changes cannot be due to medication as all of the people in the study were un-medicated when they took part.

In healthy people, the brain begins to shrink from early adulthood onwards.

Medical treatment

It is known that accelerated brain shrinkage occurs in people with bipolar disorder, or manic-depression, and schizophrenia, but until now it was not known whether these changes occurred before people became unwell. ,.....................................

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